A new optical imaging process for how to best fuse information from multiple target images into a single target image is described. The process has two primary components. First, rotating, translating and scaling each target image to register or calibrate them against a reference image and, second, determining weighing factors for each thus registered target image to select those images which add value to a final target image. The first component determines optimal rotational and translation matrices by a least squares measure using singular value decomposition. The second component determines weighing factors using correlations and statistical signal analysis techniques.