Embodiments of the claimed subject matter are directed to methods and a system that use a standardized grid of clock buffers to automatically route clocks according to a uniform clock grid throughout an ASIC of a non-uniform arrangement of non-uniformly sized logic partitions. According to one embodiment, clock sources and sinks are mapped to grid point locations and a novel grid routing process is performed to link them together. A clock routing macro is assigned to a corresponding partition and associated with the corresponding partition or logic unit according to a partition hierarchy. The underlying routing structure and resources of a clock routing macro are automatically renamed to correspond to the local partition in a script or schedule of programmed instructions, or a routing map. The position of blockages within a partition may also be detected and alternate routes for traversing the blockage may be preemptively determined as well.