A system for preventing the delivery of hypoxic gases during respiratory support of a patient includes a breathing circuit. An input device is operable by a clinician to input at least one ventilator parameter value. A fresh gas manifold is pneumatically connected to the breathing circuit and the fresh gas manifold is configured to provide at least oxygen and balanced gas to the breathing circuit. A digital signal processor is communicatively connected to the input device and the fresh gas manifold. The digital signal processor receives the input at least one ventilation parameter value, calculate a predicted oxygen concentration, and compares the predicted oxygen concentration to a predetermined minimal oxygen required threshold of the patient. A method of preventing the delivery of hypoxic gases to a patient includes providing ventilatory support to the patient through a breathing circuit. A digital signal processor receives a ventilation parameter value from an input device. The digital signal processor calculates a predicted oxygen concentration, compares the predicted oxygen concentration to a predetermined hypoxic concentration threshold and accepts the ventilation parameter value if the predicted oxygen concentration is above the predetermined hypoxic concentration threshold.