A seat cover for use with vehicle seats with or without side deployed airbags. In an example, the seat cover is made of a uni-body construction with upper and lower sections for respectively covering a seat back and seat cushion. Openings are provided in the upper and lower sections for insertion of the seat back and seat cushion. A side panel is disposed on each lateral side of the upper section that aligns with an expected path of the airbag when deployed. A frangible seam couples the panel to the remaining portion of the seat cover. The frangible seam fails at a force sufficiently less than the force of a deploying airbag. Thus when the airbag is deployed the force consumed by cleaving the frangible seam panel does not impede airbag deployment. Also included is an alignment member to position the panel in the expected path of the deploying airbag.