Invention Grant
US08771686B2 Methods for treating a disease involving choroidal neovascularization by administering an IL-6 receptor antibody
有权
通过施用IL-6受体抗体治疗涉及脉络膜新血管形成的疾病的方法
- Patent Title: Methods for treating a disease involving choroidal neovascularization by administering an IL-6 receptor antibody
- Patent Title (中): 通过施用IL-6受体抗体治疗涉及脉络膜新血管形成的疾病的方法
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Application No.: US12161733Application Date: 2007-01-26
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Publication No.: US08771686B2Publication Date: 2014-07-08
- Inventor: Susumu Ishida
- Applicant: Susumu Ishida
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2006-018543 20060127
- International Application: PCT/JP2007/051226 WO 20070126
- International Announcement: WO2007/086490 WO 20070802
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; A61K39/00
Abstract:
The present inventors focused on the fact that inflammation at the subretinal macular area enhances choroidal neovascularization, and developed pharmaceutical agents that suppress initiation or advancement of neovascularization by angiogenic factors such as VEGF. More specifically, the present inventors revealed that administering anti-IL-6 receptor monoclonal antibodies to mice treated with laser photocoagulation inhibits the development of choroidal neovascularization.
Public/Granted literature
- US20100034811A1 THERAPEUTIC AGENTS FOR DISEASES INVOLVING CHOROIDAL NEOVASCULARIZATION Public/Granted day:2010-02-11
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