Invention Grant
- Patent Title: Non-hemolytic LLO fusion proteins and methods of utilizing same
- Patent Title (中): 非溶血性LLO融合蛋白及其利用方法
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Application No.: US12213696Application Date: 2008-06-23
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Publication No.: US08771702B2Publication Date: 2014-07-08
- Inventor: Yvonne Paterson , Paulo Cesar Maciag
- Applicant: Yvonne Paterson , Paulo Cesar Maciag
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Pearl Cohen Zedek Latzer Baratz LLP
- Agent Mark S. Cohen
- Main IPC: A61K39/02
- IPC: A61K39/02 ; C07K2/00 ; C12N15/64
Abstract:
The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.
Public/Granted literature
- US20090081248A1 Non-hemolytic LLO fusion proteins and methods of utilizing same Public/Granted day:2009-03-26
Information query
