Invention Grant
- Patent Title: Soluble recombinant influenza antigens
- Patent Title (中): 可溶性重组流感抗原
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Application No.: US13001111Application Date: 2009-07-07
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Publication No.: US08771703B2Publication Date: 2014-07-08
- Inventor: Manon Couture , Nathalie Landry , Louis-Philippe Vezina , Michéle Dargis
- Applicant: Manon Couture , Nathalie Landry , Louis-Philippe Vezina , Michéle Dargis
- Applicant Address: CA Quebec
- Assignee: Medicago Inc.
- Current Assignee: Medicago Inc.
- Current Assignee Address: CA Quebec
- Agency: King & Spalding LLP
- Agent Kenneth H. Sonnenfeld
- International Application: PCT/CA2009/000941 WO 20090707
- International Announcement: WO2010/003235 WO 20100114
- Main IPC: A61K39/145
- IPC: A61K39/145 ; A61K39/00 ; C12N15/82 ; C12N15/79 ; C12N15/84 ; C12N15/44 ; C12N15/62 ; C12N15/90 ; C12N5/10 ; C07K14/005

Abstract:
The present invention provides a recombinant soluble trimeric hemagglutinin (rHA) protein comprising a hemagglutinin ectodomain and an oligomerization domain. The rHA is produced as a soluble homotrimer, and may further comprises a signal peptide and/or an endoplasmic reticulum (ER) retention signal. The invention is also directed to nucleic acids encoding the rHA of the invention, as well as vectors and chimeric constructs comprising the nucleic acid. Methods of producing the rHA are also provided. The rHA described herein may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
Public/Granted literature
- US20110104753A1 Soluble Recombinant Influenza Antigens Public/Granted day:2011-05-05
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