Invention Grant
- Patent Title: Dengue vaccine, pharmaceutical composition comprising the same, nucleotide sequence and antibody composition
- Patent Title (中): 登革热疫苗，包含其的药物组合物，核苷酸序列和抗体组成
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Application No.: US13230209Application Date: 2011-09-12
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Publication No.: US08771704B2Publication Date: 2014-07-08
- Inventor: Yee-Shin Lin
- Applicant: Yee-Shin Lin
- Applicant Address: TW Tainan
- Assignee: National Cheng Kung University
- Current Assignee: National Cheng Kung University
- Current Assignee Address: TW Tainan
- Agency: Bacon & Thomas, PLLC
- Priority: TW99130862A 20100913
- Main IPC: A61K39/295
- IPC: A61K39/295 ; A61K39/12
Abstract:
The present invention relates to a dengue vaccine, a pharmaceutical composition comprising the same, a nucleotide sequence, and an antibody composition. The dengue vaccine of the present invention includes chimeric nonstructural protein 1, which comprises N-terminus of DV NS1 from amino-acid residues 1 to 270 and C-terminus of JEV NS1 from amino-acid residues 271 to 352 (designated DJ NS1). Therefore, the dengue vaccine without autoimmunity according to the present invention is able to avoid cross-reactions with endothelial cells and platelets, and is able to shorten the bleeding time.
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