Invention Grant
- Patent Title: Enzymatic synthesis of sulfated polysaccharides
- Patent Title (中): 酶合成硫酸多糖
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Application No.: US13417641Application Date: 2012-03-12
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Publication No.: US08771995B2Publication Date: 2014-07-08
- Inventor: Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Ava M. Munoz , Jinghua Chen
- Applicant: Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Ava M. Munoz , Jinghua Chen
- Applicant Address: US NC Chapel Hill US NY Troy
- Assignee: The University of North Carolina at Chapel Hill,Rensselaer Polytechnic Institute
- Current Assignee: The University of North Carolina at Chapel Hill,Rensselaer Polytechnic Institute
- Current Assignee Address: US NC Chapel Hill US NY Troy
- Agency: Foley & Lardner LLP
- Main IPC: C12P19/04
- IPC: C12P19/04 ; C12N9/10 ; C07H21/04 ; C07K1/00
Abstract:
Heparin is synthesized from a polysaccharide comprised of a 1-4 glycosidically linked alternating polymer of uronic acid and glucosamine residues, wherein the uronic acid is selected from iduronic and glucuronic acid, wherein the glucosamine is partially N-sulfated; by a series of selective reactions catalyzed by recombinant enzymes.
Public/Granted literature
- US20120322114A1 ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES Public/Granted day:2012-12-20
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