Invention Grant
US08771997B2 Method for producing monatin using an L-amino acid aminotransferase
失效
使用L-氨基酸氨基转移酶生产莫纳甜的方法
- Patent Title: Method for producing monatin using an L-amino acid aminotransferase
- Patent Title (中): 使用L-氨基酸氨基转移酶生产莫纳甜的方法
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Application No.: US13271280Application Date: 2011-10-12
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Publication No.: US08771997B2Publication Date: 2014-07-08
- Inventor: Yasuaki Takakura , Hiroomi Ogino , Masakazu Sugiyama , Kenichi Mori , Eri Tabuchi , Koki Ishikawa , Uno Tagami , Hidemi Fujii
- Applicant: Yasuaki Takakura , Hiroomi Ogino , Masakazu Sugiyama , Kenichi Mori , Eri Tabuchi , Koki Ishikawa , Uno Tagami , Hidemi Fujii
- Applicant Address: JP Tokyo
- Assignee: Ajinomoto Co., Inc.
- Current Assignee: Ajinomoto Co., Inc.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Main IPC: C12P17/10
- IPC: C12P17/10 ; C12N9/10 ; C12P13/22 ; C12N9/00
Abstract:
The present invention provides a methodology for improving a yield of 2R,4R-Monatin. Specifically, the present invention provides a method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin or a salt thereof, comprising isomerizing the 2S,4R-Monatin to form the 2R,4R-Monatin; and the like. These production methods may further comprise condensing indole-3-pyruvate and pyruvate to form the 4R-IHOG, and deaminating a tryptophan to form the indole-3-pyruvate.
Public/Granted literature
- US20120270279A1 METHOD FOR PRODUCING MONATIN Public/Granted day:2012-10-25
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