Invention Grant
US08772031B2 Composition for reprogramming somatic cells to generate induced pluripotent stem cells, comprising Oct4 in combination with Bmi1 or its upstream regulator, and method for generating induced pluripotent stem cells using the same
有权
用于重编程体细胞以产生诱导多能干细胞的组合物，其包含Oct4与Bmi1或其上游调节子的组合，以及使用其诱导多能干细胞的方法
- Patent Title: Composition for reprogramming somatic cells to generate induced pluripotent stem cells, comprising Oct4 in combination with Bmi1 or its upstream regulator, and method for generating induced pluripotent stem cells using the same
- Patent Title (中): 用于重编程体细胞以产生诱导多能干细胞的组合物，其包含Oct4与Bmi1或其上游调节子的组合，以及使用其诱导多能干细胞的方法
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Application No.: US13890896Application Date: 2013-05-09
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Publication No.: US08772031B2Publication Date: 2014-07-08
- Inventor: Seungkwon You , Jai-Hee Moon , Jun Sung Kim , Byung Sun Yoon , Jung Han Lee , Eun Kyoung Jun , June Seok Heo
- Applicant: Korea University Research and Business Foundation
- Applicant Address: KR Seoul
- Assignee: Korea University Research and Business Foundation
- Current Assignee: Korea University Research and Business Foundation
- Current Assignee Address: KR Seoul
- Agency: Edwards Wildman Palmer LLP
- Priority: KR10-2009-0134966 20091230; KR10-2009-0134974 20091230; KR10-2009-0134976 20091230; KR10-2009-0134986 20091230
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; C12N15/00 ; C12N5/07 ; C12N5/10 ; C12N5/0735 ; C12N5/071
Abstract:
Disclosed is a composition for reprogramming somatic cells to generate embryonic stem cell-like cells, comprising: a) a Bmi1 (B cell-specific Moloney murine leukemia virus integration site 1) protein or a nucleic acid molecule coding for Bmi1; and b) an Oct4 protein or a nucleic acid molecule coding for Oct4. Also, a method is provided for reprogramming somatic cells to generate embryonic stem cell-like cells using the composition. In addition to reducing the number of the genetic factors conventionally needed, the composition and method allow the generation of pluripotent embryonic stem cell-like cells which have high potential in the cell therapy of various diseases.
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