Invention Grant
US08772048B2 Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems
失效
氟化合物通过光化学或化学方法转化为荧光团，并在生物系统中的应用
- Patent Title: Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems
- Patent Title (中): 氟化合物通过光化学或化学方法转化为荧光团，并在生物系统中的应用
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Application No.: US13409818Application Date: 2012-03-01
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Publication No.: US08772048B2Publication Date: 2014-07-08
- Inventor: Robert J. Twieg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
- Applicant: Robert J. Twieg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
- Applicant Address: US OH Kent US CA Palo Alto
- Assignee: Kent State University,Leland Stanford Junior University
- Current Assignee: Kent State University,Leland Stanford Junior University
- Current Assignee Address: US OH Kent US CA Palo Alto
- Agency: Hudak, Shunk & Farine Co. LPA
- Main IPC: G01N33/533
- IPC: G01N33/533 ; G01N33/532 ; C07K1/10
Abstract:
Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.
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