Invention Grant
US08772229B2 Methods for synthesis and uses of inhibitors of ghrelin O-acyltransferase as potential therapeutic agents for obesity and diabetes
失效
合成和使用生长素释放肽O-酰基转移酶抑制剂作为肥胖和糖尿病潜在治疗剂的方法
- Patent Title: Methods for synthesis and uses of inhibitors of ghrelin O-acyltransferase as potential therapeutic agents for obesity and diabetes
- Patent Title (中): 合成和使用生长素释放肽O-酰基转移酶抑制剂作为肥胖和糖尿病潜在治疗剂的方法
-
Application No.: US13122438Application Date: 2009-09-18
-
Publication No.: US08772229B2Publication Date: 2014-07-08
- Inventor: Philip A. Cole , Bradley P. Barnett , Yousang Hwang , Jef D. Boeke
- Applicant: Philip A. Cole , Bradley P. Barnett , Yousang Hwang , Jef D. Boeke
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Venable LLP
- Agent Stefan J. Kirchanski
- International Application: PCT/US2009/057512 WO 20090918
- International Announcement: WO2010/039461 WO 20100408
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61P3/04 ; A61K38/28 ; A61P3/10 ; A61P7/12 ; A61K38/08 ; A61K38/10 ; A61K38/16 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; A61K38/04
Abstract:
The invention provides inhibitors of ghrelin O-acyltransferase, and methods of making and using them. In some embodiments, the invention provides bisubstrate analog inhibitors of ghrelin O-acyltransferase, which can be effective in treating, for example, obesity and diabetes mellitus.
Public/Granted literature
Information query
IPC分类:
