Invention Grant
US08772235B2 Compounds having peptides conjugated to bone targeting moieties and methods of making and using thereof
有权
具有与骨靶向部分缀合的肽的化合物及其制备和使用方法
- Patent Title: Compounds having peptides conjugated to bone targeting moieties and methods of making and using thereof
- Patent Title (中): 具有与骨靶向部分缀合的肽的化合物及其制备和使用方法
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Application No.: US13501652Application Date: 2010-10-12
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Publication No.: US08772235B2Publication Date: 2014-07-08
- Inventor: Michael R. Doschak , Krishna Hari Bhandari
- Applicant: Michael R. Doschak , Krishna Hari Bhandari
- Applicant Address: CA Edmonton
- Assignee: The Governors of the University of Alberta
- Current Assignee: The Governors of the University of Alberta
- Current Assignee Address: CA Edmonton
- Agency: Gardner, Groff, Greenwald, & Villanueva P.C.
- International Application: PCT/IB2010/002708 WO 20101012
- International Announcement: WO2011/045668 WO 20110421
- Main IPC: A61K47/48
- IPC: A61K47/48 ; A61K38/23 ; A61P19/08

Abstract:
Described herein are compositions having a peptide sequence that includes at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the peptide sequence by a linker, wherein the peptide sequence is calcitonin, and wherein the composition is neutral or a pharmaceutically acceptable salt or ester thereof. In one aspect, calcitonin inhibits or slows osteoclast mediated resorptive bone loss. The compounds described herein can be used in a number of therapeutic applications including treating or preventing conditions associated with bone loss, which include, but are not limited to, osteoporosis, Paget's disease, osteolytic tumors, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Osteoarthritis, osteopenia, and hypercalcemia. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and methods of preventing bone fractures.
Public/Granted literature
- US20120270787A1 COMPOUNDS HAVING PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF Public/Granted day:2012-10-25
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