Invention Grant
US08772246B2 Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
有权
可溶性透明质酸酶糖蛋白（sHASEGP），其制备方法，用途及其组合物
- Patent Title: Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
- Patent Title (中): 可溶性透明质酸酶糖蛋白（sHASEGP），其制备方法，用途及其组合物
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Application No.: US13694005Application Date: 2012-10-18
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Publication No.: US08772246B2Publication Date: 2014-07-08
- Inventor: Louis H. Bookbinder , Anirban Kundu , Gregory I. Frost
- Applicant: Louis H. Bookbinder , Anirban Kundu , Gregory I. Frost
- Applicant Address: US CA San Diego
- Assignee: Halozyme, Inc.
- Current Assignee: Halozyme, Inc.
- Current Assignee Address: US CA San Diego
- Agency: McKenna Long & Aldridge LLP
- Agent Stephanie Seidman
- Main IPC: A61K38/14
- IPC: A61K38/14 ; A61K38/17 ; C12N9/26
Abstract:
Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. Sialated and pegylated forms of the sHASEGPs also are provided. Methods of treatment by administering sHASEGPs and modified forms thereof also are provided.
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