Invention Grant
- Patent Title: Preventive or therapeutic agent for fibrosis
- Patent Title (中): 纤维化的预防或治疗剂
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Application No.: US13824080Application Date: 2011-10-14
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Publication No.: US08772262B2Publication Date: 2014-07-08
- Inventor: Esteban C Gabazza , Tetsu Kobayashi , Hidekazu Toyobuku , Ayako Fukuda , Tetsuya Hasegawa
- Applicant: Esteban C Gabazza , Tetsu Kobayashi , Hidekazu Toyobuku , Ayako Fukuda , Tetsuya Hasegawa
- Applicant Address: JP Tsu-shi JP Tokyo
- Assignee: Mie University,Otsuka Pharmaceutical Co., Ltd.
- Current Assignee: Mie University,Otsuka Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tsu-shi JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2010-231946 20101014
- International Application: PCT/JP2011/073628 WO 20111014
- International Announcement: WO2012/050181 WO 20120419
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07H21/04
Abstract:
Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA. An siRNA having a full length of 30 or fewer nucleotides and targeting a sequence consisting of 17 to 23 consecutive bases selected from the group consisting of bases at positions 1285 to 1318, bases at positions 1398 to 1418, bases at positions 1434 to 1463, bases at positions 1548 to 1579, bases at positions 1608 to 1628, bases at positions 1700 to 1726, bases at positions 1778 to 1798, bases at positions 1806 to 1826, and bases at positions 1887 to 1907 of SEQ ID NO: 1.
Public/Granted literature
- US20130217754A1 PREVENTIVE OR THERAPEUTIC AGENT FOR FIBROSIS Public/Granted day:2013-08-22
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