Invention Grant
- Patent Title: Alkyne benzotriazole derivatives
- Patent Title (中): 炔烃苯并三唑衍生物
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Application No.: US14115109Application Date: 2012-04-30
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Publication No.: US08772276B2Publication Date: 2014-07-08
- Inventor: Scott D. Kuduk , Jason W. Skudlarek
- Applicant: Scott D. Kuduk , Jason W. Skudlarek
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Keith D. MacMillan; John C. Todaro
- International Application: PCT/US2012/035727 WO 20120430
- International Announcement: WO2012/151139 WO 20121108
- Main IPC: A61K31/397
- IPC: A61K31/397 ; A61K31/00 ; A61K31/519 ; A61K31/44 ; A61K31/41 ; C07D401/00 ; C07D257/00 ; C07D403/00 ; C07D249/08

Abstract:
The present invention is directed to alkyne benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
Public/Granted literature
- US20140088112A1 ALKYNE BENZOTRIAZOLE DERIVATIVES Public/Granted day:2014-03-27
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