Invention Grant
US08772280B2 N-aryl-2-(2-arylaminopyrimidin-4-yl)pyrrol-4-carboxamide derivatives as MPS1 kinase inhibitors
有权
作为MPS1激酶抑制剂的N-芳基-2-（2-芳基氨基嘧啶-4-基）吡咯-4-甲酰胺衍生物
- Patent Title: N-aryl-2-(2-arylaminopyrimidin-4-yl)pyrrol-4-carboxamide derivatives as MPS1 kinase inhibitors
- Patent Title (中): 作为MPS1激酶抑制剂的N-芳基-2-（2-芳基氨基嘧啶-4-基）吡咯-4-甲酰胺衍生物
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Application No.: US13260665Application Date: 2010-03-23
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Publication No.: US08772280B2Publication Date: 2014-07-08
- Inventor: Marina Caldarelli , Stefano Adele Nuvoloni , Francesca Quartieri
- Applicant: Marina Caldarelli , Stefano Adele Nuvoloni , Francesca Quartieri
- Applicant Address: IT Nerviano (MI)
- Assignee: Nerviano Medical Sciences S.R.L.
- Current Assignee: Nerviano Medical Sciences S.R.L.
- Current Assignee Address: IT Nerviano (MI)
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP09156449 20090327
- International Application: PCT/EP2010/053779 WO 20100323
- International Announcement: WO2010/108921 WO 20100930
- Main IPC: A61K31/55
- IPC: A61K31/55 ; A61K31/497 ; A61K31/505 ; C07D243/08 ; C07D403/04 ; C07D401/04
Abstract:
The present invention relates to substituted pyrrolyl-pyrimidines which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
Public/Granted literature
- US20120065192A1 N-ARYL-2-(2-ARYLAMINOPYRIMIDIN-4-YL)PYRROL-4-CARBOXAMIDE DERIVATIVES AS MPS1 KINASE INHIBITORS Public/Granted day:2012-03-15
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