Invention Grant
US08772288B2 Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors
失效
取代的螺[环烷基-1,3'-吲哚] -2'（1'H） - 酮衍生物及其作为P38丝裂原活化激酶抑制剂的用途
![Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors](/docs/US/2014-07-08/US08772288B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors
- Patent Title (中): 取代的螺[环烷基-1,3'-吲哚] -2'（1'H） - 酮衍生物及其作为P38丝裂原活化激酶抑制剂的用途
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Application No.: US12936784Application Date: 2009-04-03
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Publication No.: US08772288B2Publication Date: 2014-07-08
- Inventor: Paul Robert Eastwood , Jacob Gonzalez Rodriguez , Bernet Vidal Juan , Nuria Aguilar Izquierdo
- Applicant: Paul Robert Eastwood , Jacob Gonzalez Rodriguez , Bernet Vidal Juan , Nuria Aguilar Izquierdo
- Applicant Address: ES Barcelona
- Assignee: Almirall, S.A.
- Current Assignee: Almirall, S.A.
- Current Assignee Address: ES Barcelona
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: EP08382013 20080411
- International Application: PCT/EP2009/002458 WO 20090403
- International Announcement: WO2009/124692 WO 20091015
- Main IPC: A61K31/403
- IPC: A61K31/403 ; A61K31/4178 ; A61K31/4196 ; A61K31/4245 ; A61K31/438 ; A61K31/519 ; A61K31/5377 ; A61K31/4439 ; A61K31/437 ; A61P29/00 ; A61P1/00 ; A61P9/00 ; A61P17/06 ; C07D403/10 ; C07D209/96 ; C07D413/10 ; C07D413/14 ; C07D471/10 ; C07D487/04 ; C07D491/20 ; C07D491/107 ; C07D495/10 ; C07D487/10
![Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors](/abs-image/US/2014/07/08/US08772288B2/abs.jpg.150x150.jpg)
Abstract:
The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
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