Invention Grant
US08772294B2 Crystalline forms for 5-amino-2, 3-dihydrophthalazine-1, 4-dione sodium salt, pharmaceutical preparations containing the same and method for the production of said forms
有权
5-氨基-2,3-二氢酞嗪-1,4-二酮钠盐的结晶形式，含有该物质的药物制剂和生产所述形式的方法
- Patent Title: Crystalline forms for 5-amino-2, 3-dihydrophthalazine-1, 4-dione sodium salt, pharmaceutical preparations containing the same and method for the production of said forms
- Patent Title (中): 5-氨基-2,3-二氢酞嗪-1,4-二酮钠盐的结晶形式，含有该物质的药物制剂和生产所述形式的方法
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Application No.: US13582522Application Date: 2011-03-01
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Publication No.: US08772294B2Publication Date: 2014-07-08
- Inventor: Josef Breu , Wolfgang Brysch , Astrid Kaiser , Beate Ludescher , Gerrit Maass , Thomas Martin , Wolfgang Milius , Michael Niedermaier
- Applicant: Josef Breu , Wolfgang Brysch , Astrid Kaiser , Beate Ludescher , Gerrit Maass , Thomas Martin , Wolfgang Milius , Michael Niedermaier
- Applicant Address: CH Zurich
- Assignee: MetrioPharm AG
- Current Assignee: MetrioPharm AG
- Current Assignee Address: CH Zurich
- Agency: Millen, White, Zelano & Branigan, P.C.
- Priority: EP10002067 20100301; EP10075744 20101125
- International Application: PCT/EP2011/001124 WO 20110301
- International Announcement: WO2011/107295 WO 20110909
- Main IPC: A01N43/58
- IPC: A01N43/58 ; A61K31/50 ; C07D237/30
Abstract:
The invention relates to the provision of two novel crystalline forms I and II for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt. Surprisingly, it was discovered that form I and form II have differing immunological effects. This advantageous property is useful for immunospecific applications. In addition, both forms have advantageous physicochemical properties, which are useful in the production, further processing and/or use of a pharmaceutical preparation of form I or form II or a mixture of both.
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