Invention Grant
US08772311B2 Harmine derivatives, intermediates used in their preparations, preparation processes and use thereof
有权
哈曼衍生物，其制备中使用的中间体，制备方法及其用途
- Patent Title: Harmine derivatives, intermediates used in their preparations, preparation processes and use thereof
- Patent Title (中): 哈曼衍生物，其制备中使用的中间体，制备方法及其用途
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Application No.: US10559824Application Date: 2004-06-02
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Publication No.: US08772311B2Publication Date: 2014-07-08
- Inventor: Jialin Wu , Qi Chen , Rihui Cao , Fusheng Yu , Zihou Wang , Wenlie Peng
- Applicant: Jialin Wu , Qi Chen , Rihui Cao , Fusheng Yu , Zihou Wang , Wenlie Peng
- Applicant Address: CN Urumqi
- Assignee: Xinjiang Huashidan Pharmaceutical Research Co., Ltd.
- Current Assignee: Xinjiang Huashidan Pharmaceutical Research Co., Ltd.
- Current Assignee Address: CN Urumqi
- Agency: Weaver Austin Villeneuve & Sampson LLP
- Priority: CN3136406 20030602
- International Application: PCT/CN2004/000591 WO 20040602
- International Announcement: WO2004/106335 WO 20041209
- Main IPC: A61K31/437
- IPC: A61K31/437 ; C07D487/04
Abstract:
This invention relates to compounds of general formula (I), wherein R1, R2, R3, R4 and R5 are as defined in the specification; intermediates used in their preparation, preparation processes and use thereof. The present invention produces new harmine derivatives with enhanced antitumor activity and lower nervous system toxicity by structurally modification of the parent structure of β-carboline of harmines at position 1, 2, 3, 7 and 9. The compounds of the present invention can be prepared easily with high yield. They can be used in manufacture of a variety of antitumor medicines and medicines used in treatment of tumor diseases in combination of light or radiation therapy.
Public/Granted literature
- US20090227619A1 Harmine derivatives, intermediates used in their preparations, preparation processes and use therefo Public/Granted day:2009-09-10
Information query
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