Invention Grant
US08772316B2 Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A)
有权
取代的6,7-二烷氧基-3-异喹啉醇衍生物作为磷酸二酯酶10（PDE10A）的抑制剂
- Patent Title: Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A)
- Patent Title (中): 取代的6,7-二烷氧基-3-异喹啉醇衍生物作为磷酸二酯酶10（PDE10A）的抑制剂
-
Application No.: US13399351Application Date: 2012-02-17
-
Publication No.: US08772316B2Publication Date: 2014-07-08
- Inventor: Bertrand Leblond , John E. Donello , Cédric Chauvignac , Thierry Taverne , Eric Beausoleil , Anne-Sophie Casagrande , Laurent Désiré , Matthew P. Pando , Rong Yang
- Applicant: Bertrand Leblond , John E. Donello , Cédric Chauvignac , Thierry Taverne , Eric Beausoleil , Anne-Sophie Casagrande , Laurent Désiré , Matthew P. Pando , Rong Yang
- Applicant Address: US CA Irvine FR Paris
- Assignee: Allergan, Inc.,Exonhit Therapeutics SA
- Current Assignee: Allergan, Inc.,Exonhit Therapeutics SA
- Current Assignee Address: US CA Irvine FR Paris
- Agent Krishna Banerjee
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/41 ; C07D491/00 ; C07D498/00 ; C07D515/00
Abstract:
The invention relates to compounds of the formula wherein R′, R1, through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type II diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases.
Public/Granted literature
- US20120214837A1 SUBSTITUTED 6,7-DIALKOXY-3-ISOQUINOLINOL DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE10A) Public/Granted day:2012-08-23
Information query
IPC分类:
