Invention Grant
US08772318B2 Methods and compositions related to targeting monoacylglycerol lipase
失效
与单酰基甘油脂肪酶靶向相关的方法和组合物
- Patent Title: Methods and compositions related to targeting monoacylglycerol lipase
- Patent Title (中): 与单酰基甘油脂肪酶靶向相关的方法和组合物
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Application No.: US12998642Application Date: 2009-11-10
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Publication No.: US08772318B2Publication Date: 2014-07-08
- Inventor: Benjamin F. Cravatt , Jonathan Z. Long , Weiwei Li , Daniel K. Nomura
- Applicant: Benjamin F. Cravatt , Jonathan Z. Long , Weiwei Li , Daniel K. Nomura
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agent Hugh Wang; Thomas Fitting
- International Application: PCT/US2009/006045 WO 20091110
- International Announcement: WO2010/056309 WO 20100520
- Main IPC: A61K31/443
- IPC: A61K31/443 ; C07D405/06
Abstract:
This invention provides compounds that selectively inhibit monoacylglycerol lipase (MAGL). The invention also provides methods of using the MAGL selective inhibitors to stimulate 2-Arachidonoylglycerol (2-AG) mediated endocannabinoid signaling in vivo, and to treat conditions that are associated with or linked to endocannabinoid signaling. The invention additionally provides methods of treating cancer or inhibiting tumor growth by targeting MAGL with MAGL specific inhibitors. The invention further provides methods of screening for MAGL inhibitors with improved biochemical and pharmaceutical properties.
Public/Granted literature
- US20110275650A1 METHODS AND COMPOSITIONS RELATED TO TARGETING MONOACYLGLYCEROL LIPASE Public/Granted day:2011-11-10
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