Invention Grant
- Patent Title: Oximes for treatment of peripheral and central nervous system exposure to acetyl cholinesterase inhibitors
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Application No.: US13197550Application Date: 2011-08-03
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Publication No.: US08772345B2Publication Date: 2014-07-08
- Inventor: Stanton F. McHardy , Richard M. Corbett , Donald M. Maxwell , Michael W. Tidwell , Bismarck Campos , Christopher J. Bemben
- Applicant: Stanton F. McHardy , Richard M. Corbett , Donald M. Maxwell , Michael W. Tidwell , Bismarck Campos , Christopher J. Bemben
- Applicant Address: US TX San Antonio
- Assignee: Southwest Research Institute
- Current Assignee: Southwest Research Institute
- Current Assignee Address: US TX San Antonio
- Agency: Grossman, Tucker et al
- Main IPC: A01N33/24
- IPC: A01N33/24 ; A61K31/15
Abstract:
The present invention relates to non-charged oxime compounds which are acetyl cholinesterase (AChE) reactivators of inhibited AChE and which protect against organophosphate poisoning both peripherally and in the central nervous system. Also disclosed are pharmaceutical compositions and methods for preparing the reactivator compounds and associated intermediates.
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