Invention Grant
US08772468B2 Splice variant specific messenger RNA transcripts as biomarkers of parkinson's disease
有权
接头变体特异性信使RNA转录物作为帕金森病的生物标志物
- Patent Title: Splice variant specific messenger RNA transcripts as biomarkers of parkinson's disease
- Patent Title (中): 接头变体特异性信使RNA转录物作为帕金森病的生物标志物
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Application No.: US13240821Application Date: 2011-09-22
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Publication No.: US08772468B2Publication Date: 2014-07-08
- Inventor: Judith A. Potashkin
- Applicant: Judith A. Potashkin
- Applicant Address: US IL North Chicago
- Assignee: Rosalind Franklin University of Medicine and Science
- Current Assignee: Rosalind Franklin University of Medicine and Science
- Current Assignee Address: US IL North Chicago
- Agency: Ungaretti & Harris LLP
- Agent Joseph A. Fuchs
- Main IPC: C07H21/04
- IPC: C07H21/04

Abstract:
The present invention provides a method and a diagnostic kit for diagnosing the presence of Parkinson's disease in a human subject. The method includes the steps of: (1) extracting RNA molecules from a blood sample of the human subject to define a test sample; (2) measuring the amount of each RNA molecule having Sequence ID Nos. 1-14 in the test sample; (3) comparing the amount of each of the RNA molecules having Sequence ID Nos. 1-14 to the amount of RNA molecules having Sequence ID Nos. 1-14 present in a control sample to determine how many of the RNA molecules of Sequence ID Nos. 1-14 are present in a significant amount in the test sample greater or less than in the control sample to define a number of biomarkers; and (4) diagnosing the presence of Parkinson's disease in the human subject if the number of biomarkers is equal to or greater than five.
Public/Granted literature
- US20130079235A1 SPLICE VARIANT SPECIFIC MESSENGER RNA TRANSCRIPTS AS BIOMARKERS OF PARKINSON'S DISEASE Public/Granted day:2013-03-28
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