Invention Grant
- Patent Title: Process for the preparation of solifenacin succinate
- Patent Title (中): 琥珀酸索非那新的制备方法
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Application No.: US13261551Application Date: 2011-06-20
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Publication No.: US08772491B2Publication Date: 2014-07-08
- Inventor: Anand Gopalkrishna Kamat , Joseph Prabahar Koilpillai , Naga Trinadhachari Ganala , Venkata Lakshmi Upputuri , Venkata Balalji Boddu , Sivakumaran Meenakshisunderam
- Applicant: Anand Gopalkrishna Kamat , Joseph Prabahar Koilpillai , Naga Trinadhachari Ganala , Venkata Lakshmi Upputuri , Venkata Balalji Boddu , Sivakumaran Meenakshisunderam
- Applicant Address: IN Hyderabad
- Assignee: Aurobindo Pharma Ltd
- Current Assignee: Aurobindo Pharma Ltd
- Current Assignee Address: IN Hyderabad
- Agent Jay R Akhave
- Priority: IN1815/CHE/2010 20100628
- International Application: PCT/IB2011/001472 WO 20110620
- International Announcement: WO2012/001481 WO 20120105
- Main IPC: C07D453/02
- IPC: C07D453/02
Abstract:
The present invention relates to a process for the preparation of Solifenacin succinate by condensing a compound of formula (IVb) with (RS)-3-quinuclidinol, wherein, R represents methyl, ethyl, isopropyl; to produce a diastereomeric mixture of (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic acid (3RS)-1-azabicyclo[2.2.2]oct-3-yl ester, which is treated with succinic acid in a solvent or mixture of solvents to produce optically pure Solifenacin succinate, Formula (X).
Public/Granted literature
- US20130123502A1 NOVEL PROCESS FOR THE PREPARATION OF SOLIFENACIN SUCCINATE Public/Granted day:2013-05-16
Information query
