Invention Grant
US08772504B2 Substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators
有权
取代的苯并恶唑，苯并咪唑，恶唑并吡啶和咪唑并吡啶衍生物作为γ分泌酶调节剂
- Patent Title: Substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators
- Patent Title (中): 取代的苯并恶唑，苯并咪唑，恶唑并吡啶和咪唑并吡啶衍生物作为γ分泌酶调节剂
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Application No.: US13144557Application Date: 2010-02-15
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Publication No.: US08772504B2Publication Date: 2014-07-08
- Inventor: Henricus Jacobus Maria Gijsen , François Paul Bischoff , Wei Zhuang , Sven Franciscus Anna Van Brandt , Michel Surkyn , Mirko Zaja , Didier Jean-Claude Berthelot , Michel Anna Jozef De Cleyn , Gregor James MacDonald , Daniel Oehlrich
- Applicant: Henricus Jacobus Maria Gijsen , François Paul Bischoff , Wei Zhuang , Sven Franciscus Anna Van Brandt , Michel Surkyn , Mirko Zaja , Didier Jean-Claude Berthelot , Michel Anna Jozef De Cleyn , Gregor James MacDonald , Daniel Oehlrich
- Applicant Address: US NJ Titusville GB Brentford, Middlesex
- Assignee: Janssen Pharmaceuticals, Inc.,Cellzome Limited
- Current Assignee: Janssen Pharmaceuticals, Inc.,Cellzome Limited
- Current Assignee Address: US NJ Titusville GB Brentford, Middlesex
- Agency: Baker & Hostetler LLP
- Priority: EP09153188 20090219; EP09163409 20090622
- International Application: PCT/EP2010/051843 WO 20100215
- International Announcement: WO2010/094647 WO 20100826
- Main IPC: C07D235/00
- IPC: C07D235/00 ; C07D403/02
Abstract:
The present invention is concerned with novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives of Formula (I) wherein R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 and Z have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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