Invention Grant
US08772512B2 Crystallisation process for 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene
有权
1-（＆bgr-D-吡喃葡萄糖基）-4-甲基-3- [5-（4-氟苯基）-2-噻吩甲基]苯的结晶过程
![Crystallisation process for 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene](/docs/US/2014-07-08/US08772512B2/abs.jpg.600x600.jpg)
- Patent Title: Crystallisation process for 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene
- Patent Title (中): 1-（＆bgr-D-吡喃葡萄糖基）-4-甲基-3- [5-（4-氟苯基）-2-噻吩甲基]苯的结晶过程
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Application No.: US13382658Application Date: 2010-07-08
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Publication No.: US08772512B2Publication Date: 2014-07-08
- Inventor: Thomas Joachim Landewald Rammeloo , Ruben De Keyser , Gustaaf Jozef Petrus Schildermans
- Applicant: Thomas Joachim Landewald Rammeloo , Ruben De Keyser , Gustaaf Jozef Petrus Schildermans
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Priority: EP09165125 20090710
- International Application: PCT/EP2010/059817 WO 20100708
- International Announcement: WO2011/003976 WO 20110113
- Main IPC: C07D409/10
- IPC: C07D409/10 ; C07D309/10
![Crystallisation process for 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene](/abs-image/US/2014/07/08/US08772512B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a crystallization procedure to obtain 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene hemihydrate crystals having a narrow particle size distribution and improved flowability, bulk and tap density properties.
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