Invention Grant
- Patent Title: Process for the production of bimatoprost
- Patent Title (中): 生育比马前列素的过程
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Application No.: US12999112Application Date: 2009-06-10
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Publication No.: US08772544B2Publication Date: 2014-07-08
- Inventor: Dominic De Souza , Martin Albert , Hubert Sturm
- Applicant: Dominic De Souza , Martin Albert , Hubert Sturm
- Applicant Address: CH Basel
- Assignee: Sandoz AG
- Current Assignee: Sandoz AG
- Current Assignee Address: CH Basel
- Agency: Manelli Selter PLLC
- Agent Jeffrey S. Melcher
- Priority: EP08158675 20080620
- International Application: PCT/EP2009/057186 WO 20090610
- International Announcement: WO2009/153206 WO 20091223
- Main IPC: C07C233/05
- IPC: C07C233/05
Abstract:
The present invention relates to a process for the purification of crude bimatoprost to obtain pure bimatoprost comprising a chromatography, preferably a chromatography using an achiral stationary phase and an eluent comprising an alcohol and an apolar solvent; and crystallization of the product obtained the chromatography to obtain pure bimatoprost.
Public/Granted literature
- US20110178340A1 IMPROVED PROCESS FOR THE PRODUCTION OF BIMATOPROST Public/Granted day:2011-07-21
Information query
