A solid-state image pickup device includes a pixel array unit that includes photoelectric conversion elements and in which a plurality of pixels are arranged in rows and columns that output, as pixel signals, electrical signals obtained by photoelectric conversion performed by amplifier elements to which pixel power supply voltage is supplied and that drive signal lines, a pixel power supply unit that generates the pixel power supply voltage from power supply voltage, the pixel power supply voltage being lower than the power supply voltage, and that supplies the pixel power supply voltage to the amplifier elements in the plurality of pixels, and a pixel signal read unit that reads pixel signals from the plurality of pixels.