System and method are disclosed for synchronization of a transmitting device and a receiving device that communicate with each other via pulse modulation. The synchronization technique entails the transmitting device sending one or more quasi-periodic pulse sequences to the receiving device. A quasi-periodic pulse sequence is based on a substantially periodic pulse sequence, and may include some non-periodic pulses or not include some periodic pulses. The transmitting device may transmit frames each including a preamble that comprises one or more quasi-periodic pulse sequences, and a data payload that may comprise data. The receiving device receives the signal, generates samples of the signal, and detects the quasi-periodic pulse sequences in the received signal by analyzing samples based on a sample associated with a pulse and the period associated with the substantially periodic pulse sequence. The receiving device is further able to detect frames based on the detection of the sequence, and extract data therefrom.