A system and method for multiple vehicles to be dispatched and routed to multiple destinations, with or without constraints, containing a software core, which uses bounded geographic regions (“BGRs”) and Node Pairs to explicitly optimize, in two dimensions, for user desired dependent variables, by analyzing variance due to standard and user-defined independent variables. The invention stores Node Pair data, and can use error function, feedback, and ANOVA/MANOVA to create a tightly convergent dispatching and navigation solution.