Various embodiments of the present invention are directed to systems and methods for enabling software applications running on separate devices to exchange data via multiple data communication methods. In various embodiments, a data communication system is provided comprising multiple data communication devices running one or more software applications and communication manager middleware. In various embodiments, the data communication system permits the software applications to exchange data without knowledge of the actual method and/or protocol used to exchange a given set of data, and intelligently manage the exchange of data between software applications by, among other things, transmitting sets of data using a preferred communication method selected based on one or more message attributes or communication method attributes.