A multi-mode data card includes at least two mode modules, and also includes an external interface module and an interface control module. The external interface module connects to the interface control module. The external interface is configured to connect with computer for data interaction; the interface control module is equipped with at least two channels, and said at least two channels connects to said at least two mode modules respectively. The interface control module is configured to: when the multi-mode data card is calibrated, connect the external interface module with the channel corresponding to the mode module to be calibrated, and switch the multi-mode data card to the mode to be calibrated. A method for calibrating multi-mode data card is also provided in the present invention.