Instrumented networks, computer systems and platforms having target subjects (devices, transactions, services, users, organizations) are disclosed. A security orchestration service generates runtime operational integrity profiles representing and identifying a level of threat or contextual trustworthiness, at near real time, of subjects and applications on the instrumented target platform. Methods and systems are disclosed for calculating security risks by determining subject reputation scores. In an embodiment, a system receives a query for a reputation score of a subject, initiates directed queries to external information management systems to interrogate attributes associated with the subject, and analyzes responses. The system receives a hierarchical subject reputation score based on a calculus of risk and returns a reputation token. In another embodiment, a method provides real time attestation of a subject's reputation to a service provider using an endpoint trust agent, and a trust orchestrator comprising a reputation broker and a trust broker.