Invention Grant
US08778967B2 Chemokine receptor binding heterocyclic compounds with enhanced efficacy
有权
趋化因子受体结合杂环化合物具有增强的疗效
- Patent Title: Chemokine receptor binding heterocyclic compounds with enhanced efficacy
- Patent Title (中): 趋化因子受体结合杂环化合物具有增强的疗效
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Application No.: US13358041Application Date: 2012-01-25
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Publication No.: US08778967B2Publication Date: 2014-07-15
- Inventor: Gary Bridger , Renato T Skelj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R Wilson , Jason B Crawford , Ernest J McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R Di Fluri
- Applicant: Gary Bridger , Renato T Skelj , Al Kaller , Curtis Harwig , David Bogucki , Trevor R Wilson , Jason B Crawford , Ernest J McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria R Di Fluri
- Applicant Address: US MA Cambridge
- Assignee: Genzyme Corporation
- Current Assignee: Genzyme Corporation
- Current Assignee Address: US MA Cambridge
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: A61K31/4709
- IPC: A61K31/4709 ; C07D403/12
Abstract:
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
Public/Granted literature
- US20120301427A1 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY Public/Granted day:2012-11-29
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