Invention Grant
- Patent Title: Azabicyclo compound and salt thereof
- Patent Title (中): 氮杂双环化合物及其盐
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Application No.: US13378527Application Date: 2010-07-09
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Publication No.: US08779142B2Publication Date: 2014-07-15
- Inventor: Makoto Kitade , Shuichi Ohkubo , Chihoko Yoshimura , Satoshi Yamashita , Hiromi Oshiumi , Takao Uno , Yuichi Kawai
- Applicant: Makoto Kitade , Shuichi Ohkubo , Chihoko Yoshimura , Satoshi Yamashita , Hiromi Oshiumi , Takao Uno , Yuichi Kawai
- Applicant Address: JP Tokyo
- Assignee: Taiho Pharmaceutical Co., Ltd.
- Current Assignee: Taiho Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2009-164196 20090710
- International Application: PCT/JP2010/004466 WO 20100709
- International Announcement: WO2011/004610 WO 20110113
- Main IPC: A61K31/4365
- IPC: A61K31/4365 ; C07D471/04

Abstract:
It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein X1 represents CH or N; any one of X2, X3 and X4 represents N, and the others represent CH; any one or two of Y1, Y2, Y3 and Y4 represent C—R4, and the others are the same or different and represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; R2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R3 and R4 represent —CO—R5 or the like.
Public/Granted literature
- US20120108589A1 AZABICYCLO COMPOUND AND SALT THEREOF Public/Granted day:2012-05-03
Information query
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