Invention Grant
- Patent Title: Cilostazol cocrystals and compositions
- Patent Title (中): 西洛他唑共晶体和组合物
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Application No.: US13643213Application Date: 2011-04-28
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Publication No.: US08779146B2Publication Date: 2014-07-15
- Inventor: Alan Chorlton , Christopher Frampton , Daniel Gooding , Joanne Holland
- Applicant: Alan Chorlton , Christopher Frampton , Daniel Gooding , Joanne Holland
- Applicant Address: GB
- Assignee: Nuformix Limited
- Current Assignee: Nuformix Limited
- Current Assignee Address: GB
- Agency: J.A. Lindeman & Co., PLLC
- International Application: PCT/IB2011/001430 WO 20110428
- International Announcement: WO2011/158110 WO 20111222
- Main IPC: A61K31/04
- IPC: A61K31/04 ; C07D215/04 ; C07D215/20 ; A61K31/4709
Abstract:
The invention relates to improvements of the physiochemical and/or the pharmaceutical properties of cilostazol. Disclosed herein are several new compositions and cocrystals of cilostazol, including: a 1:1 cilostazol gentisic acid cocrystal, a 1:1:1 cilostazol gentisic acid H2O cocrystal, a 1:1 cilostazol 4-hydroxybenzoic acid cocrystal, and a 1:1 cilostazol 2,4-dihydroxybenzoic acid cocrystal. The therapeutic methods and uses of these cilostazol cocrystals are described as well as therapeutic compositions containing them.
Public/Granted literature
- US20130203806A1 CILOSTAZOL COCRYSTALS AND COMPOSITIONS Public/Granted day:2013-08-08
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