An operating method of a semiconductor device that includes a plurality of memory cell blocks, comprising selecting one of the memory cell blocks in response to a program command, performing a pre-program operation and a pre-erase operation so that threshold voltages of memory cells included in the selected memory cell block are distributed between a first positive voltage and a first negative voltage, supplying a program permission voltage to a first group of bit lines and supplying a program inhibition voltage to a second group of bit lines, wherein the first group and the second group are mutually exclusive, and supplying a positive program voltage to a selected word line coupled to memory cells.