Techniques for performing channel interleaving to achieve similar SINRs for multiple code blocks are described. In one design, a transmitter station (e.g., a base station or a UE) determines a plurality of resource groups assigned for data transmission. Each resource group includes a plurality of resource elements formed by a cluster of subcarriers in a time interval. The transmitter station partitions a transport block into a plurality of code blocks, processes each code block to obtain data symbols for that code block, and maps the data symbols for each code block to at least one resource element in each of the plurality of resource groups. The transmitter station transmits the mapped data symbols for the plurality of code blocks to a receiver station. In one design, the transmitter station receives an ACK or a NACK for the transport block and retransmits all code blocks if a NACK is received.