Among other things, one or more techniques and/or systems are described for dynamically adjusting one or more X-ray acquisition parameters of an X-ray imaging modality. During a first portion of an examination of an object, the object is examined using a first set of X-ray acquisition parameters and a first image is generated. A region-of-interest is identified in the first image and one or more X-ray acquisition parameters are adjusted as a function of the identified region-of-interest to establish a second set of X-ray acquisition parameters. During a second portion of the examination of the object, the object is examined using the second set of X-ray acquisition parameters to generate a second image. In this way, X-ray acquisition parameters can be adjusted in real-time or ‘on the fly’ to obtain a (more) desired image.