A system, a method and a recording medium for driving a programmable logic controller are disclosed. This system includes a server and an adaptive unit electrically connected to the server. When determining that a programmable logic controller is connected, a hardware layer management module of the adaptive unit informs the server. The server outputs a controller query data to query the programmable logic controller through the hardware layer management module. The server generates a control data conforming to a specification of the programmable logic controller according to a controller response data of the programmable logic controller, for the hardware layer management module to control the programmable logic controller.