Memoization may be deployed using a configuration file or database that identifies functions to memorize, and in some cases, includes input and result values for those functions. The configuration file or database may be created by profiling target code and offline or otherwise separate analysis of the profiling results. The configuration file may be used by an execution environment to identify which functions to memorize during execution. The offline or separate analysis of the profiling results may enable more sophisticated analysis than could otherwise be performed in parallel with executing the target code, including historical analysis of multiple instances of the target code and sophisticated cost/benefit analysis.