Invention Grant
US08795658B2 Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral pH
有权
在弱酸性至中性pH下通过组氨酸的水性制剂稳定免疫球蛋白
- Patent Title: Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral pH
- Patent Title (中): 在弱酸性至中性pH下通过组氨酸的水性制剂稳定免疫球蛋白
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Application No.: US13235314Application Date: 2011-09-16
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Publication No.: US08795658B2Publication Date: 2014-08-05
- Inventor: Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Wolfgang Teschner , Hans-Peter Schwarz
- Applicant: Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Wolfgang Teschner , Hans-Peter Schwarz
- Applicant Address: US IL Deerfield unknown Glattpark (Opfikon)
- Assignee: Baxter International Inc.,Baxter Healthcare SA
- Current Assignee: Baxter International Inc.,Baxter Healthcare SA
- Current Assignee Address: US IL Deerfield unknown Glattpark (Opfikon)
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K47/02 ; A61K47/18 ; A61K9/00
Abstract:
The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration.
Public/Granted literature
- US20120076772A1 STABILIZATION OF IMMUNOGLOBULINS THROUGH AQUEOUS FORMULATION WITH HISTIDINE AT WEAK ACIDIC TO NEUTRAL PH Public/Granted day:2012-03-29
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