Invention Grant
US08795686B2 Stable, dried rotavirus vaccine, compositions and process for preparation thereof
有权
稳定的干轮状病毒疫苗，组合物及其制备方法
- Patent Title: Stable, dried rotavirus vaccine, compositions and process for preparation thereof
- Patent Title (中): 稳定的干轮状病毒疫苗，组合物及其制备方法
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Application No.: US13056557Application Date: 2009-11-06
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Publication No.: US08795686B2Publication Date: 2014-08-05
- Inventor: Rajeev M. Dhere , Sambhaji S. Pisal , Jagdish K. Zade
- Applicant: Rajeev M. Dhere , Sambhaji S. Pisal , Jagdish K. Zade
- Applicant Address: IN Pune
- Assignee: Serum Institute of India
- Current Assignee: Serum Institute of India
- Current Assignee Address: IN Pune
- Agency: Knobbe Martens Olson & Bear LLP
- Priority: IN2365/MUM/2008 20081107
- International Application: PCT/IN2009/000629 WO 20091106
- International Announcement: WO2010/146598 WO 20101223
- Main IPC: A61K39/15
- IPC: A61K39/15
Abstract:
The present invention provides novel lyophilized rotavirus vaccine formulations and methods of their preparation. The formulations include vaccine stabilizers, resulting in a vaccine formulation with enhanced stability and minimal loss of potency. The rotavirus vaccine formulations comprise an advantageous ratio of a disaccharide (such as sucrose) to an amino acid (such as glycine). The lyophilization results in a virus formulation with 100% virus preservation and residual moisture from about 0.8% to 1.4%.
Public/Granted literature
- US20110177119A1 STABLE, DRIED ROTAVIRUS VACCINE, COMPOSITIONS AND PROCESS FOR PREPARATION THEREOF Public/Granted day:2011-07-21
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