Invention Grant
US08795687B2 West Nile virus prM-E signal peptide facilitating the efficient assembly, maturation, and release of virus-like particles (VLPs)
有权
西尼罗病毒prM-E信号肽促进病毒样颗粒（VLP）的有效装配，成熟和释放，
- Patent Title: West Nile virus prM-E signal peptide facilitating the efficient assembly, maturation, and release of virus-like particles (VLPs)
- Patent Title (中): 西尼罗病毒prM-E信号肽促进病毒样颗粒（VLP）的有效装配，成熟和释放，
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Application No.: US12741479Application Date: 2008-11-07
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Publication No.: US08795687B2Publication Date: 2014-08-05
- Inventor: Asato Kojima , Hidehiro Takahashi , Toyokazu Ishikawa
- Applicant: Asato Kojima , Hidehiro Takahashi , Toyokazu Ishikawa
- Applicant Address: JP Tokyo JP Suita
- Assignee: Japan as Represented by the Director-General of National Institute of Infections Diseases,The Research Foundation for Microbial Diseases of Osaka University
- Current Assignee: Japan as Represented by the Director-General of National Institute of Infections Diseases,The Research Foundation for Microbial Diseases of Osaka University
- Current Assignee Address: JP Tokyo JP Suita
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2007-290169 20071107
- International Application: PCT/JP2008/070354 WO 20081107
- International Announcement: WO2009/060961 WO 20090514
- Main IPC: A61K39/12
- IPC: A61K39/12 ; A61K38/00
Abstract:
The present invention provides virus-like particles (VLP) highly secreting or producing signal peptide obtained by altering a signal sequence derived from West Nile virus (WNV), the signal peptide, a WNV VLP secretion expression vector containing a nucleic acid encoding prM protein and E protein, a WNP VLP highly secreting or producing animal cell line harboring the vector, a WNV vaccine containing WNV VLP obtained by the cell line as an active ingredient, and a WNV DNA vaccine containing the VLP secretion expression vector as an active ingredient.
Public/Granted literature
- US20100247559A1 WEST NILE VIRUS VACCINE, AND METHOD FOR PRODUCTION THEREOF Public/Granted day:2010-09-30
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