Invention Grant
- Patent Title: Influenza A virus vaccines and inhibitors
- Patent Title (中): 甲型流感病毒疫苗和抑制剂
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Application No.: US13907472Application Date: 2013-05-31
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Publication No.: US08796008B2Publication Date: 2014-08-05
- Inventor: Gaetano Montelione , Kalyan Das , Edward Arnold , Li-Chung Ma , Rong Xiao , Rei-Lin Kuo , Robert M. Krug , Karen Y. Twu
- Applicant: Board of Regents, The University of Texas System , Rutgers, The State University of New Jersey
- Applicant Address: US TX Austin US NJ New Brunswick
- Assignee: Board of Regents, The University of Texas System,Rutgers, The State University of New Jersey
- Current Assignee: Board of Regents, The University of Texas System,Rutgers, The State University of New Jersey
- Current Assignee Address: US TX Austin US NJ New Brunswick
- Agency: Chalker Flores, LLP
- Agent Chainey P. Singleton; Edwin S. Flores
- Main IPC: C12N7/04
- IPC: C12N7/04 ; C12N15/00 ; C12N15/09
Abstract:
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
Public/Granted literature
- US20140044745A1 Influenza A Virus Vaccines and Inhibitors Public/Granted day:2014-02-13
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