Invention Grant
US08796022B2 Generation of functional basal forebrain cholinergic neurons from stem cells
有权
从干细胞中产生功能性基底前脑胆碱能神经元
- Patent Title: Generation of functional basal forebrain cholinergic neurons from stem cells
- Patent Title (中): 从干细胞中产生功能性基底前脑胆碱能神经元
-
Application No.: US13178734Application Date: 2011-07-08
-
Publication No.: US08796022B2Publication Date: 2014-08-05
- Inventor: Christopher Bissonnette , John Kessler
- Applicant: Christopher Bissonnette , John Kessler
- Applicant Address: US IL Evanston
- Assignee: Northwestern University
- Current Assignee: Northwestern University
- Current Assignee Address: US IL Evanston
- Agency: Casimir Jones S.C.
- Main IPC: C12N5/0793
- IPC: C12N5/0793 ; C12N15/85 ; A61P25/28 ; A61K35/30 ; C12N5/0797 ; C12N5/0735
Abstract:
The present invention provides method, compositions, and systems for generating basal forebrain cholinergic neurons (BFCNs) using FGF8, SHH, LXH8, GBX1, or vectors encoding these ligands, as well as using such BFCNs to treat neurological disorders such as Alzheimer's disease.
Public/Granted literature
- US20120237484A1 Generation of Functional Basal Forebrain Cholinergic Neurons From Stem Cells Public/Granted day:2012-09-20
Information query
