Invention Grant
- Patent Title: Imidazobenzazepine CGRP receptor antagonists
- Patent Title (中): 咪唑苯并吖庚因CGRP受体拮抗剂
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Application No.: US12867332Application Date: 2009-02-06
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Publication No.: US08796260B2Publication Date: 2014-08-05
- Inventor: Howard G. Selnick , Ian M. Bell
- Applicant: Howard G. Selnick , Ian M. Bell
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent H. Eric Fischer; John C. Todaro
- International Application: PCT/US2009/033288 WO 20090206
- International Announcement: WO2009/105348 WO 20090827
- Main IPC: A61K31/55
- IPC: A61K31/55 ; C07D487/12

Abstract:
Compounds of Formula I: I (where variables R1A, R1B, R2, R3, R4, A, and Z are as defined herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.
Public/Granted literature
- US20100324023A1 IMIDAZOBENZAZEPINE CGRP RECEPTOR ANTAGONISTS Public/Granted day:2010-12-23
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