Invention Grant
US08796263B2 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors
有权
4-氨基喹唑啉-2-基-1-吡唑-4-羧酸化合物作为脯氨酰羟化酶抑制剂
- Patent Title: 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors
- Patent Title (中): 4-氨基喹唑啉-2-基-1-吡唑-4-羧酸化合物作为脯氨酰羟化酶抑制剂
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Application No.: US13816747Application Date: 2011-08-12
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Publication No.: US08796263B2Publication Date: 2014-08-05
- Inventor: Michael H. Rabinowitz , Mark D. Rosen , Kyle T. Tarantino , Hariharan Venkatesan
- Applicant: Michael H. Rabinowitz , Mark D. Rosen , Kyle T. Tarantino , Hariharan Venkatesan
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- International Application: PCT/US2011/047626 WO 20110812
- International Announcement: WO2012/021830 WO 20120216
- Main IPC: A61K31/55
- IPC: A61K31/55 ; A61K31/517 ; A61K31/54 ; C07D401/00 ; C07D413/00 ; C07D243/08 ; C07D403/00
Abstract:
Aminoquinazolinyl compounds of formula (I) are described, which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.
Public/Granted literature
- US20130143871A1 4-AMINOQUINAZOLIN-2-YL-1-PYRRAZOLE-4-CARBOXYLIC ACID COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS Public/Granted day:2013-06-06
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